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Desomorphine is a semi-synthetic opioid commercialized by Roche, with powerful, fast-acting effects, such as sedation and analgesia. It was first discovered and patented by a German team working for Knoll in 1920 but was not generally recognized. It was later synthesized in 1932 by Lyndon Frederick Small. Small also successfully patented it in 1934 in the United States. Desomorphine was used in Switzerland under the brand name Permonid and was described as having a fast onset and a short duration of action, with relatively little nausea compared to equivalent doses of morphine. Dose-by-dose is eight to ten times more potent than morphine. Order now

Desomorphine is a morphine Analogue where the 6-hydroxyl group and the 7,8 double bond have been reduced. The traditional synthesis of desomorphine starts from α-Chlorocodide, which is obtained by treating thionyl chloride with codeine. By catalytic reduction, α-Chlorocodide gives Dihydrodesoxycodeine, which yields desomorphine on demethylation.

Desomorphine has been created by the public as a street drug. In that context, it is commonly called “krokodil” (Russian for crocodile), named for the scaly sores and necrosis that develop around the injection site.

What is Desomorphine used for?

Desomorphine was previously used in Switzerland and Russia for the treatment of severe pain. While medical usage of desomorphine was terminated in 1981, during the final years leading up to that it was being used to treat a single patient in Bern, Switzerland with a rare illness.  While desomorphine was found to be faster-acting and more effective than morphine for the rapid relief of severe pain, its shorter duration of action and the relatively more severe respiratory depression produced at equianalgesic doses, as well as a high incidence of other side effects such as hypotension and urinary retention, were felt to outweigh any potential advantages. how to buy krokodil

Side effects Desomorphine

• skin
• blood vessels
• bone and muscles

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